ANALYSIS OF THE EFFECT OF KALLIDINOGENASE ON THE SEVERITY OF ISOLATED CLOSED HEAD INJURY, PROGNOSIS OF DEATH, CONSCIOUSNESS, AND BRAIN EDEMA

Main Article Content

Kenjaev L.T ., Ibragimov N.K., Muhammadova M.B.

Abstract

Disability of victims of CTBI is one of the most important factors determining the urgency of the problem of injuries. The consequences of CTBI manifest themselves in the long term and are characterized by morphological and functional changes in the brain and its structures, which determine various clinical manifestations. The consequences of CTBI are "highly soluble sediments" that accumulate over the years, essentially determining the health status of the population and determining the humanitarian, social and economic significance of brain injuries. Kallidinogenase - tissue kallikrein, a component of the kallikrein - kinin system (KKS), has a protective effect against cerebral ischemia.


       

Article Details

Section
Articles

References

Bivaltsev A.V, Kalinin A. A., Belvix Ye. G. Craniocerebral trauma. FGBOU VO IGMU Minzdrava Rossii, 2018. 616.833.1-001-089(0758)

Bratton S.L., Chestnut R.M., Ghajar J. Et al. Guidelines for the management of severe traumatic brain injury. IX. Cerebral perfusion thresholds // J. Neurotrauma. — 2007. — 24. — S59-S64.

Belyaevsky1 A. D, Lebedeva1 Ye. A, Belousova M. Ye Cytokines, Oxidative Stress and Antioxidant Defense in Isolated and Concomitant Brain Injury General resuscitation 5 (6) p 36-39.

Cherednichenko T.V. Bayun Yu.V. Bukriy A.O. Management of patients with closed craniocerebral injury in the acute period of 2019 world neurology 614:616-001.

Chao J, Chao L. Experimental Therapy with Tissue Kallikrein against Cerebral Ischemia. Front Biosci. 2006;11:1323-7.

Eriksson E.A., Barletta J.F., Figueroa B.E. et al. Cerebral perfusion pressure and intracranial pressure are not surrogates for brain tissue oxygenation in traumatic brain injury // Clin. Neurophysiol. — 2012. — 123. — 1255-1260.