CHRONIC OSTEOMYELITIS

Abstract

Chronic osteomyelitis is a major threat to orthopaedic surgery and is difficult to cure due to biofilm formation of micro-organisms. Staphylococcus aureus is the main causative agent for chronic osteomyelitis. There are different types of osteomyelitis which results after the performance of orthopaedic surgery. However, the long-term delivery of conventional systemic antibiotics causes accumulated toxicity and microbes developed resistance against antibiotics. So, the conventional antibiotics cannot penetrate due to poor blood supply in the sequestrum area, the effective bactericidal concentration cannot be reached, thus the delivery system fails and new methodologies are adapted to overcome the problems. Local drug delivery system plays a promising role in the treatment of osteomyelitis