EFFECT OF K-72 AND BUTADION ON FORMALIN-INDUCED INFLAMMATION IN WHITE MICE WHEN ADMINISTERED ORALLY

Abstract

The second series of experiments was conducted on white rats. The anti-inflammatory effect of the drug was assessed by changes in the volume of rat paws, which was recorded oncometrically in dynamics. In the control group of rats, the average increase in paw volume 6 hours after formalin administration was 0.79+0.34 ml, and in rats that had previously received K-72 in doses of 50, 100 and 150 mg/kg, the average increase in paw volume was 0.45+0.028; 0.39-0.020; 0.37+0.030 ml, respectively. As can be seen, the anti-inflammatory activity of K-72 is equal to 41.1% at a dose of 50 mg/kg, 49.6% at a dose of 100 mg/kg and 52.6% at a dose of 150 mg/kg. At the same time, in the group of animals receiving butadion, the average increase in paw volume was 0.56 + 0.033 ml, and the anti-inflammatory activity was equal to 29.1%, and in the group of animals receiving voltaren, the average increase in paw volume was 0.44_+ 0.024 ml, while the anti-inflammatory activity was equal to 43.6%. For indomethacin, these indicators were equal to 0.44_+ 0.021 and 42.8%, respectively.